The lines of research developed in diagnosis and therapeutics in endocrinology and metabolism cover a wide range of topics that are essential for the understanding and treatment of endocrine disorders. From investigating new biomarkers for the early diagnosis of endocrine diseases to developing innovative and more effective therapies the lines of research developed are key to advance knowledge and improve the clinical management of these conditions. Issues such as optimizing treatments for diabetes, hypothyroidism, polycystic ovary syndrome, and osteoporosis are key areas of interest. In addition, research in molecular endocrinology and genetics offers crucial insights into the genetic underpinnings of endocrine diseases, contributing to more personalized and precise therapeutic approaches. In short, the lines of research developed in diagnosis and therapeutics in endocrinology and metabolism are essential to promote significant advances in the understanding and treatment of endocrine diseases, directly benefiting the health and well-being of patients.
The Line of Research in Epidemiology in Metabolism and Endocrinology aims to study the descriptive aspects of the distribution, impact on healthcare and morbidity and mortality, risk factors and social determinants of diseases and health conditions related to endocrinology and metabolism. Some of the health conditions addressed in this Line of Research include diabetes and associated morbidities, including obesity, rare endocrinopathies, and intersex and transgender people. The traditional and emerging risk factors for these health conditions can be studied, as well as the epidemiology of the life cycle of the mechanisms of the developmental origin of adult diseases. This line of research is relevant because it is essential to clarify the natural history of a disease or condition and its risk factors to establish prevention strategies.
The line of research in physiology, pathophysiology and etiopathogenesis in endocrinology and metabolism focuses on understanding the standard physiological processes and pathological changes of the endocrine system. By means of investigating the underlying mechanisms of endocrine diseases such as diabetes, thyroid disorders, and hormone imbalances, this line of research seeks to identify the fundamental causes of these conditions. By exploring the patterns in hormone regulation, the function of endocrine organs, and the metabolic pathways involved, researchers can elucidate the molecular and genetic grounds of endocrine diseases. This approach is essential for developing more targeted and effective therapeutic strategies, as well as contributing to the prevention and early diagnosis of endocrine disorders. Ultimately, developing research in this field is critical to advancing scientific knowledge and improving the clinical care of patients with endocrine diseases.
| Supervisors | Lines of Research | Research Projects |
| André F Reis Fernando Giuffrida Sergio Atalah Dib Regina Moisés |
Diagnosis and therapy | Diagnosis and treatment of monogenic and polygenic forms of diabetes mellitus and its complications. |
| Janete Cerutti Rodrigo Pinheiro Araldi Martins |
Diagnosis and therapy | Characterization of genetic and epigenetic events associated with the genesis and progression of thyroid cancer in adulthood and in the pediatric age group. Applications in clinical practice by using strategies of functional genomics and in vitro and in vivo models. |
| Julio Abucham | Diagnosis and therapy | Development and application of new methods for early detection and treatment of hypothalamus and pituitary gland disorders. |
| Magnus Regios da Silva | Diagnosis and therapy | Disorders/Differences of Sex Development (DSD) focused on Turner Syndrome and Klinefelter Syndrome. |
| Maria Teresa Zanella Glaucia Carneiro |
Diagnosis and therapy | Studies on the control and treatment of obesity and associated morbidities. |
| Rosa Paula Biscola | Diagnosis and therapy | Development and validation of diagnostic and therapeutic methods in patients with thyroid nodule and thyroid carcinoma (differentiated, undifferentiated and medullary carcinoma). |
| Sergio Setsuo Maeda Marise L Castro |
Diagnosis and therapy | Study of the bone structure and of the biomechanical factors related to bone fragility. |
| Bianca de A Pititto Patricia M Dualib Sergio A Dib |
Epidemiology | Epidemiology of Diabetes and Cardiometabolic Risk Factors. |
| Magnus Regios da Silva | Epidemiology | Health and Citizenship for Trans People. |
| Claudio Kater Flavia Amanda |
Physiology, pathophysiology and etiopathogenesis | Adrenal Glands: physiology and pathophysiology. |
| João Maciel Caroline Serrano Carolina Janovsky Lucas Leite Cunha Susan Chow Lindsey |
Physiology, pathophysiology and etiopathogenesis | Thyroid: Physiology and Pathophysiology. |
| Giselle Giannocco | Physiology, pathophysiology and etiopathogenesis | Physiological and pathophysiological studies of thyroid dysfunctions, cross-sex hormone therapy and endocrine disruptors in different experimental models (in vivo and in vitro). Actions in the central nervous system, control of metabolism and control of reproduction. |
| Rui B Maciel João Maciel Susan Chow Lindsey |
Physiology, pathophysiology and etiopathogenesis | Medullary thyroid carcinoma: a revisiting of the clinical matters, molecular biology, biochemistry and developmental biology after the findings of molecular genetics. |
| Julio Abucham | Physiology, pathophysiology and etiopathogenesis | Molecular bases of hypothalamus and pituitary gland pathologies. |
| Marise Lazaretti Castro Sergio S Maeda |
Physiology, pathophysiology and etiopathogenesis | Endocrine regulation of mineral homeostasis. |
| Sergio Atalah Dib Regina Moisés Patricia Dualib |
Physiology, pathophysiology and etiopathogenesis | Diabetes mellitus: etiopathogenesis and pathophysiology. |
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